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The Pulse of Southern California

Who is playing in NFL Week 5? Here’s the full schedule – NBC Los Angeles

BySoCal Chronicle

Oct 3, 2025



It’s time for the second month of the 2025 NFL season.

The regular season is already through four weeks, and now things start to heat up. From bye weeks beginning to overseas games continuing, the upcoming slate has a little bit of everything.

What’s in store for Week 5? Here’s the full schedule ahead:

Week 5 kicks off with an NFC West matchup on Thursday Night Football for the second straight week. After the Seattle Seahawks beat the Arizona Cardinals last Thursday, this week it’ll be the Los Angeles Rams (3-1) hosting the San Francisco 49ers (3-1).

Looking ahead to Sunday, the European portion of the schedule continues with the first of three games in London. The Minnesota Vikings (2-2), who lost in Dublin last week, will stay in British Isles to face off with the Cleveland Browns (1-3) at Tottenham Hotspur Stadium.

The headlining events on Sunday include three untraditional matchups. Bo Nix and the Denver Broncos (2-2) will visit Jalen Hurts and the Philadelphia Eagles (4-0) in the early slate of six games. Later in the afternoon, the Seahawks (3-1) and Tampa Bay Buccaneers (3-1) will face off in Seattle and the Washington Commanders (2-2) will visit the Los Angeles Chargers (3-1).

NBC’s Sunday Night Football will be a battle of division rivals. Josh Allen and the undefeated Buffalo Bills (4-0) will host Drake Maye and the New England Patriots (2-2).

Week 5 will conclude with a Monday Night Football matchup between Patrick Mahomes’ Kansas City Chiefs (2-2) and Trevor Lawrence’s Jacksonville Jaguars (3-1) in Duval County.

The Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers will be the first teams on a bye.

The multi-platinum, GRAMMY Award-winning singer stars in the musical show opening for NBC’s Sunday Night Football for the 13th consecutive NFL season.



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